# A1CF

Source: https://onco.cc/targets/a1cf/  
OnCo record `a1cf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.77, genetic association 0.58, somatic mutation 0.50).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: APOBEC1 complementation factor; ACF64; ACF65; APOBEC1CF
- Tags: cancer-genes-wave
- Symbol: A1CF
- Class: other
- Biology: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Location: Nucleus; Endoplasmic reticulum; Cytoplasm (UniProt). Locus 10q11.23 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24086: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24086
- UniProt Q9NQ94: https://www.uniprot.org/uniprotkb/Q9NQ94/entry
- NCBI Gene 29974: https://www.ncbi.nlm.nih.gov/gene/29974
- Ensembl ENSG00000148584: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148584

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/a1cf.json