# ABCC1

Source: https://onco.cc/targets/abcc1/  
OnCo record `abcc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.84, clinical 0.12).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ATP binding cassette subfamily C member 1 (ABCC1 blood group); ATP-binding cassette sub-family C member 1; GS-X; MRP1
- Tags: cancer-genes-wave
- Symbol: ABCC1
- Class: enzyme
- Biology: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centres in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 16p13.11 (HGNC).
- Where found: Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:51: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:51
- UniProt P33527: https://www.uniprot.org/uniprotkb/P33527/entry
- NCBI Gene 4363: https://www.ncbi.nlm.nih.gov/gene/4363
- Ensembl ENSG00000103222: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103222

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- pathways: [Drug efflux pumps (ABC transporters)](https://onco.cc/pathways/drug-efflux-pumps/)

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JSON: https://onco.cc/api/v1/entities/abcc1.json