# ABCC10

Source: https://onco.cc/targets/abcc10/  
OnCo record `abcc10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ABCC10 (ATP-binding cassette sub-family C member 10) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ATP binding cassette subfamily C member 10; ATP-binding cassette sub-family C member 10; EST182763; MRP7; SIMRP7
- Tags: cancer-genes-wave
- Symbol: ABCC10
- Class: other
- Biology: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier. Mediates intercellular propagation of antiviral immune signalling in early stages of infection. In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signalling to inhibit viral replication. This innate signalling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection. Location: Cell membrane; Basolateral cell membrane; Basal cell membrane (UniProt). Locus 6p21.1 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:52: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:52
- UniProt Q5T3U5: https://www.uniprot.org/uniprotkb/Q5T3U5/entry
- NCBI Gene 89845: https://www.ncbi.nlm.nih.gov/gene/89845
- Ensembl ENSG00000124574: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124574

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/abcc10.json