# ABCG2

Source: https://onco.cc/targets/abcg2/  
OnCo record `abcg2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ABCG2 (Broad substrate specificity ATP-binding cassette transporter ABCG2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ATP binding cassette subfamily G member 2 (JR blood group); Broad substrate specificity ATP-binding cassette transporter ABCG2; EST157481; CD338
- Tags: cancer-genes-wave
- Symbol: ABCG2
- Class: other
- Biology: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Location: Cell membrane; Apical cell membrane; Mitochondrion membrane (UniProt). Locus 4q22.1 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:74: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:74
- UniProt Q9UNQ0: https://www.uniprot.org/uniprotkb/Q9UNQ0/entry
- NCBI Gene 9429: https://www.ncbi.nlm.nih.gov/gene/9429
- Ensembl ENSG00000118777: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118777

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- pathways: [Drug efflux pumps (ABC transporters)](https://onco.cc/pathways/drug-efflux-pumps/), [Epithelial-mesenchymal transition & drug efflux](https://onco.cc/pathways/emt/), [The blood-brain barrier & brain metastasis](https://onco.cc/pathways/blood-brain-barrier-metastasis/)

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JSON: https://onco.cc/api/v1/entities/abcg2.json