# ABI1

Source: https://onco.cc/targets/abi1/  
OnCo record `abi1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: abl interactor 1; Abl interactor 1; E3B1; ABI-1; SSH3BP1
- Tags: cancer-genes-wave
- Symbol: ABI1
- Class: other
- Biology: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Location: Cytoplasm; Nucleus; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 10p12.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11320: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11320
- UniProt Q8IZP0: https://www.uniprot.org/uniprotkb/Q8IZP0/entry
- NCBI Gene 10006: https://www.ncbi.nlm.nih.gov/gene/10006
- Ensembl ENSG00000136754: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136754

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/abi1.json