# ACSL6

Source: https://onco.cc/targets/acsl6/  
OnCo record `acsl6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.

## Summary

Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Liposarcoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: acyl-CoA synthetase long chain family member 6; Long-chain-fatty-acid--CoA ligase 6; KIAA0837; ACS2; LACS5; LACS2; FACL6
- Tags: cancer-genes-wave
- Symbol: ACSL6
- Class: oncogene
- Biology: Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).
- Where found: Sarcomas: IntOGen driver in 1 cohort (LIPO); Liposarcoma: IntOGen driver in 1 cohort (LIPO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16496: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16496
- UniProt Q9UKU0: https://www.uniprot.org/uniprotkb/Q9UKU0/entry
- NCBI Gene 23305: https://www.ncbi.nlm.nih.gov/gene/23305
- Ensembl ENSG00000164398: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164398

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Liposarcoma](https://onco.cc/cancers/liposarcoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/acsl6.json