# ACTA1

Source: https://onco.cc/targets/acta1/  
OnCo record `acta1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTA1 (Actin, alpha skeletal muscle) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: actin alpha 1, skeletal muscle; Actin, alpha skeletal muscle; NEM3
- Tags: cancer-genes-wave
- Symbol: ACTA1
- Class: enzyme
- Biology: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q42.13 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:129: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:129
- UniProt P68133: https://www.uniprot.org/uniprotkb/P68133/entry
- NCBI Gene 58: https://www.ncbi.nlm.nih.gov/gene/58
- Ensembl ENSG00000143632: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143632

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

---
JSON: https://onco.cc/api/v1/entities/acta1.json