# ACTA2

Source: https://onco.cc/targets/acta2/  
OnCo record `acta2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.

## Summary

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: actin alpha 2, smooth muscle; Actin, aortic smooth muscle; ACTSA
- Tags: cancer-genes-wave
- Symbol: ACTA2
- Class: enzyme
- Biology: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 10q23.31 (HGNC).
- Where found: Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:130: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:130
- UniProt P62736: https://www.uniprot.org/uniprotkb/P62736/entry
- NCBI Gene 59: https://www.ncbi.nlm.nih.gov/gene/59
- Ensembl ENSG00000107796: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107796

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)

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JSON: https://onco.cc/api/v1/entities/acta2.json