# ACTB

Source: https://onco.cc/targets/actb/  
OnCo record `actb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTB (Actin, cytoplasmic 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: actin beta; Actin, cytoplasmic 1
- Tags: cancer-genes-wave
- Symbol: ACTB
- Class: enzyme
- Biology: Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. Location: Cytoplasm, cytoskeleton; Nucleus (UniProt). Locus 7p22.1 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:132: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:132
- UniProt P60709: https://www.uniprot.org/uniprotkb/P60709/entry
- NCBI Gene 60: https://www.ncbi.nlm.nih.gov/gene/60
- Ensembl ENSG00000075624: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075624

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/actb.json