# ACTG1

Source: https://onco.cc/targets/actg1/  
OnCo record `actg1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: actin gamma 1; Actin, cytoplasmic 2; DFNA20; DFNA26
- Tags: cancer-genes-wave
- Symbol: ACTG1
- Class: enzyme
- Biology: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17q25.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:144: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:144
- UniProt P63261: https://www.uniprot.org/uniprotkb/P63261/entry
- NCBI Gene 71: https://www.ncbi.nlm.nih.gov/gene/71
- Ensembl ENSG00000184009: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184009

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/actg1.json