# ACTL6A

Source: https://onco.cc/targets/actl6a/  
OnCo record `actl6a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTL6A (Actin-like protein 6A) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Non-small-cell lung cancer.

## Summary

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin and Panobinostat.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: actin like 6A; Actin-like protein 6A; Actl6; BAF53A; Arp4; Baf53a; INO80K; SMARCN1
- Tags: cancer-genes-wave
- Symbol: ACTL6A
- Class: transcription
- Biology: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. Location: Nucleus (UniProt). Locus 3q26.33 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24124: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24124
- UniProt O96019: https://www.uniprot.org/uniprotkb/O96019/entry
- NCBI Gene 86: https://www.ncbi.nlm.nih.gov/gene/86
- Ensembl ENSG00000136518: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136518

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/actl6a.json