# ACTM-838

Source: https://onco.cc/drugs/actm-838/  
OnCo record `actm-838` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ACTM-838 is an experimental engineered attenuated Salmonella Typhimurium from Actym Therapeutics, in phase 1 trials for advanced solid tumours; its current status is not stated.

## Summary

ACTM-838 is an engineered attenuated Salmonella Typhimurium (bacterial delivery, STACT platform) from Actym Therapeutics. An engineered, weakened Salmonella given into a vein that gathers in tumours and delivers two immune payloads there: an engineered IL-15 complex and a constitutively active STING. Its furthest stage is phase 1, for advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Registry lists NCT06336148 as terminated: "Sponsor's strategic business decision". The company website still says ACTM-838 "is currently in a Phase 1a/b trial". Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: ACTM-838
- Modality: Engineered attenuated Salmonella Typhimurium (bacterial delivery, STACT platform)
- Mechanism: An engineered, weakened Salmonella given into a vein that gathers in tumours and delivers two immune payloads there: an engineered IL-15 complex and a constitutively active STING.

## Sources

- Actym Therapeutics: actymthera.com: https://www.actymthera.com/pipeline
- Actym Therapeutics: synapse.patsnap.com: https://synapse.patsnap.com/article/actym-gets-ind-clearance-for-phase-1-trial-of-actm-838-in-solid-tumor-patients
- Actym Therapeutics: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT06336148
- ClinicalTrials.gov: trials of ACTM-838: https://clinicaltrials.gov/search?intr=ACTM-838

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- companies: [Actym Therapeutics](https://onco.cc/companies/actym-therapeutics/)
- trials: [A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors](https://onco.cc/trials/nct06336148/)

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JSON: https://onco.cc/api/v1/entities/actm-838.json