# ADH1B

Source: https://onco.cc/targets/adh1b/  
OnCo record `adh1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ADH1B (All-trans-retinol dehydrogenase [NAD(+)] ADH1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.

## Summary

Catalyses the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyse the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyses in the oxidative direction with higher efficiency.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.74).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: alcohol dehydrogenase 1B (class I), beta polypeptide; All-trans-retinol dehydrogenase [NAD(+)] ADH1B; ADH2
- Tags: cancer-genes-wave
- Symbol: ADH1B
- Class: enzyme
- Biology: Catalyses the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyse the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyses in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. Location: Cytoplasm (UniProt). Locus 4q23 (HGNC).
- Where found: Oesophageal cancer: Open Targets association 0.56 with oesophageal cancer (MONDO_0007576)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:250: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:250
- UniProt P00325: https://www.uniprot.org/uniprotkb/P00325/entry
- NCBI Gene 125: https://www.ncbi.nlm.nih.gov/gene/125
- Ensembl ENSG00000196616: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196616

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Oesophageal cancer](https://onco.cc/cancers/esophageal/)

---
JSON: https://onco.cc/api/v1/entities/adh1b.json