# ADRA2B

Source: https://onco.cc/targets/adra2b/  
OnCo record `adra2b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ADRA2B (Alpha-2B adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.11, animal model 0.43, clinical 0.81).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: adrenoceptor alpha 2B; Alpha-2B adrenergic receptor; ADRARL1; ADRA2L1; ADRA2RL1
- Tags: cancer-genes-wave
- Symbol: ADRA2B
- Class: other
- Biology: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Location: Cell membrane (UniProt). Locus 2q11.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:282: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:282
- UniProt P18089: https://www.uniprot.org/uniprotkb/P18089/entry
- NCBI Gene 151: https://www.ncbi.nlm.nih.gov/gene/151
- Ensembl ENSG00000274286: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000274286

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/adra2b.json