# AGCT1531

Source: https://onco.cc/trials/agct1531/  
OnCo record `agct1531` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AGCT1531 is testing two ways to spare people with germ cell tumours from long-term harm: watching low-risk patients after surgery and giving chemotherapy only if the tumour returns, and swapping cisplatin for carboplatin, which is kinder to hearing, in standard-risk disease; it is still recruiting.

## Summary

AGCT1531 is a Children's Oncology Group phase 3 study run with adult cooperative groups for malignant extracranial germ cell tumours from birth to age 50. Low-risk patients (stage I) enter active surveillance after surgery with chemotherapy reserved for relapse. Standard-risk patients are randomised to bleomycin, etoposide and carboplatin or bleomycin, etoposide and cisplatin, with paediatric and adult dosing schedules; the primary endpoints are event-free and overall survival at two years, and ototoxicity is a central secondary endpoint.

The registry gives an estimated enrolment of 1,780 with a primary completion date of June 2027 and no results. The corpus's childhood germ cell tumour page cites the AGCT1531 stratum for surveillance with chemotherapy only at relapse.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-22
- Also known as: COG AGCT1531
- Tags: soc-trials
- Registry id: NCT03067181
- Phase: 3
- Setting: Malignant germ cell tumours in children, adolescents and adults up to 50: active surveillance after surgery for low-risk stage I disease, and a randomised comparison of carboplatin against cisplatin with bleomycin and etoposide for standard-risk disease, with hearing loss as a key outcome
- Sponsor: Children's Oncology Group
- Enrolled: 1780

## Sources

- ClinicalTrials.gov NCT03067181: https://clinicaltrials.gov/study/NCT03067181

## Connected records

- cancers: [Childhood cancers (all types)](https://onco.cc/cancers/childhood-cancers/), [Extragonadal germ cell tumour](https://onco.cc/cancers/extragonadal-germ-cell-tumour/), [Germ cell tumours of childhood and adolescence (extracranial and CNS)](https://onco.cc/cancers/paediatric-germ-cell-tumours/), [Testicular germ cell tumours](https://onco.cc/cancers/testicular/)
- technologies: [Active surveillance](https://onco.cc/technologies/active-surveillance/), [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Bleomycin](https://onco.cc/drugs/bleomycin/), [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Etoposide](https://onco.cc/drugs/etoposide/)
- institutions: [Children's Oncology Group (COG)](https://onco.cc/institutions/childrens-oncology-group/)

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