# AGGF1

Source: https://onco.cc/targets/aggf1/  
OnCo record `aggf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.89, animal model 0.41, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: angiogenic factor with G-patch and FHA domains 1; Angiogenic factor with G patch and FHA domains 1; VG5Q; HSU84971; FLJ10283; GPATC7; GPATCH7
- Tags: cancer-genes-wave
- Symbol: AGGF1
- Class: other
- Biology: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Location: Cytoplasm; Secreted (UniProt). Locus 5q13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24684: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24684
- UniProt Q8N302: https://www.uniprot.org/uniprotkb/Q8N302/entry
- NCBI Gene 55109: https://www.ncbi.nlm.nih.gov/gene/55109
- Ensembl ENSG00000164252: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164252

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/aggf1.json