# AGR2

Source: https://onco.cc/targets/agr2/  
OnCo record `agr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AGR2 (Anterior gradient protein 2 homolog) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Tamoxifen.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: anterior gradient 2, protein disulphide isomerase family member; Anterior gradient protein 2 homolog; XAG-2; HAG-2; AG2; PDIA17
- Tags: cancer-genes-wave
- Symbol: AGR2
- Class: other
- Biology: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. Location: Secreted; Endoplasmic reticulum (UniProt). Locus 7p21.1 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:328: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:328
- UniProt O95994: https://www.uniprot.org/uniprotkb/O95994/entry
- NCBI Gene 10551: https://www.ncbi.nlm.nih.gov/gene/10551
- Ensembl ENSG00000106541: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106541

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/agr2.json