# AGTRAP

Source: https://onco.cc/targets/agtrap/  
OnCo record `agtrap` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.89, animal model 0.26, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: angiotensin II receptor associated protein; Type-1 angiotensin II receptor-associated protein; ATRAP
- Tags: cancer-genes-wave
- Symbol: AGTRAP
- Class: other
- Biology: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle membrane (UniProt). Locus 1p36.22 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13539: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13539
- UniProt Q6RW13: https://www.uniprot.org/uniprotkb/Q6RW13/entry
- NCBI Gene 57085: https://www.ncbi.nlm.nih.gov/gene/57085
- Ensembl ENSG00000177674: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177674

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/agtrap.json