# AIMP2

Source: https://onco.cc/targets/aimp2/  
OnCo record `aimp2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.

## Summary

Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: aminoacyl tRNA synthetase complex interacting multifunctional protein 2; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; p38; PRO0992; JTV-1; JTV1
- Tags: cancer-genes-wave
- Symbol: AIMP2
- Class: other
- Biology: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Location: Cytoplasm, cytosol; Nucleus (UniProt). Locus 7p22.1 (HGNC).
- Where found: Lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20609: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20609
- UniProt Q13155: https://www.uniprot.org/uniprotkb/Q13155/entry
- NCBI Gene 7965: https://www.ncbi.nlm.nih.gov/gene/7965
- Ensembl ENSG00000106305: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106305

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/aimp2.json