# AKAP9

Source: https://onco.cc/targets/akap9/  
OnCo record `akap9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AKAP9 (A-kinase anchor protein 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Renal cell carcinoma and 5 more.

## Summary

Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.89, genetic association 0.41, somatic mutation 0.50). IntOGen calls it a driver in 10 cohorts (5 activating, 4 loss-of-function), covering Basal Cell Carcinoma, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: A-kinase anchoring protein 9; A-kinase anchor protein 9; KIAA0803; AKAP350; AKAP450; CG-NAP; YOTIAO; HYPERION; PRKA9; MU-RMS-40.16A; PPP1R45; LQT11
- Tags: cancer-genes-wave
- Symbol: AKAP9
- Class: oncogene
- Biology: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarised cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery. Location: Golgi apparatus; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 7q21.2 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Breast cancer: IntOGen driver in 1 cohort (BRCA); Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Oesophageal cancer: IntOGen driver in 1 cohort (ESCA); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:379: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:379
- UniProt Q99996: https://www.uniprot.org/uniprotkb/Q99996/entry
- NCBI Gene 10142: https://www.ncbi.nlm.nih.gov/gene/10142
- Ensembl ENSG00000127914: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127914

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/akap9.json