# Alberto Gabizon

Source: https://onco.cc/people/alberto-gabizon/  
OnCo record `alberto-gabizon` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The clinician half of the partnership that turned a liposome chemistry idea into Doxil, and the person who did the trials that showed it behaved differently in patients from free doxorubicin.

## Summary

Alberto Gabizon worked with Yechezkel Barenholz at the Hebrew University on pegylated liposomal doxorubicin and then took it into patients, establishing the pharmacokinetics that distinguish it from free doxorubicin: a long circulation half-life, accumulation in tumour tissue, and a toxicity profile in which hand-foot syndrome and mucositis replace alopecia and cardiac damage. The product was approved by the FDA in 1995 and remains standard in relapsed ovarian cancer, used as a single agent or with carboplatin, trabectedin or bevacizumab, and as the comparator arm in modern trials including MIRASOL. He continues to work at Shaare Zedek Medical Center on nanomedicine pharmacology and combination strategies.

## Fields

- Kind: Person
- Last checked: 2026-09-25
- Tags: clinician-scientist; drug-delivery
- Role: Oncologist, Shaare Zedek Medical Center; professor, Hebrew University-Hadassah Medical School
- Specialisms: Liposomal drug delivery; Pharmacokinetics of nanomedicines; Ovarian and breast cancer; Early-phase trials

## Sources

- Shaare Zedek Medical Center: https://www.szmc.org.il/eng/
- PubMed author search: https://pubmed.ncbi.nlm.nih.gov/?term=Gabizon%20A%5BAuthor%5D%20liposomal%20doxorubicin
- Europe PMC author and affiliation search: https://europepmc.org/search?query=AUTH%3A%22Gabizon%20A%22%20AND%20liposomal

## Connected records

- cancers: [Kaposi sarcoma](https://onco.cc/cancers/kaposi-sarcoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- fronts: [Chemotherapy](https://onco.cc/fronts/chemotherapy/), [Drug Discovery Platforms](https://onco.cc/fronts/drug-discovery/)
- drugs: [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Pegylated liposomal doxorubicin](https://onco.cc/drugs/pegylated-liposomal-doxorubicin/)
- institutions: [Hebrew University of Jerusalem](https://onco.cc/institutions/hebrew-university-of-jerusalem/), [Shaare Zedek Medical Center](https://onco.cc/institutions/shaare-zedek/)

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