# ALCAM

Source: https://onco.cc/targets/alcam/  
OnCo record `alcam` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ALCAM (CD166 antigen) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Fluorouracil.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: activated leukocyte cell adhesion molecule; CD166 antigen; CD166
- Tags: cancer-genes-wave
- Symbol: ALCAM
- Class: other
- Biology: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal haematopoietic stem cell engraftment in the bone marrow. Location: Cell membrane; Cell projection, axon; Cell projection, dendrite; Secreted (UniProt). Locus 3q13.11 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:400: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:400
- UniProt Q13740: https://www.uniprot.org/uniprotkb/Q13740/entry
- NCBI Gene 214: https://www.ncbi.nlm.nih.gov/gene/214
- Ensembl ENSG00000170017: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170017

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/alcam.json