# Alliance N0574 (NCCTG N0574)

Source: https://onco.cc/trials/alliance-n0574/  
OnCo record `alliance-n0574` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

N0574 showed that adding whole-brain radiotherapy to radiosurgery for a few brain metastases damages memory and thinking without lengthening life, and radiosurgery alone became the standard.

## Summary

N0574 randomised 213 patients with one to three brain metastases to stereotactic radiosurgery alone or radiosurgery plus whole-brain radiotherapy. Cognitive deterioration at three months, the primary endpoint, occurred in 63.5 percent after radiosurgery alone and 91.7 percent after the combination; whole-brain treatment improved intracranial control but median survival did not differ (10.4 vs 7.4 months, not significant) (Brown and colleagues, JAMA 2016).

## Fields

- Kind: Trial
- Status: positive
- Last checked: 2026-09-16
- Tags: radiation-wave2
- Registry id: NCT00377156
- Phase: 3
- Setting: One to three brain metastases: stereotactic radiosurgery alone versus radiosurgery plus whole-brain radiotherapy
- Sponsor: Alliance for Clinical Trials in Oncology
- Enrolled: 213
- Result: Cognitive deterioration at 3 months 63.5% (SRS alone) vs 91.7% (SRS plus WBRT); no survival difference.
- Outcomes: Cognitive deterioration at 3 months: Radiosurgery alone 63.5% vs Radiosurgery plus whole-brain radiotherapy 91.7%

## Sources

- ClinicalTrials.gov NCT00377156: https://clinicaltrials.gov/study/NCT00377156
- JAMA 2016: https://doi.org/10.1001/jama.2016.9839

## Connected records

- cancers: [Brain and spinal cord tumours (all types)](https://onco.cc/cancers/brain-tumours/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- technologies: [Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)](https://onco.cc/technologies/radiosurgery-srs/)
- terms: [Stereotactic radiosurgery (SRS)](https://onco.cc/terms/stereotactic-radiosurgery/), [Whole-brain radiotherapy (WBRT)](https://onco.cc/terms/wbrt/)

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