# BRCAplus (Ambry Genetics)

Source: https://onco.cc/drugs/ambry-brcaplus/  
OnCo record `ambry-brcaplus` (Test). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A blood test from Ambry Genetics for 13 genes linked to inherited breast cancer, including BRCA1, BRCA2, PALB2 and TP53.

## Summary

Registered in the NIH Genetic Testing Registry as GTR000560503.11 (updated 12 November 2024) by Ambry Genetics: ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53. Recorded as a test developed by the laboratory; not among the FDA-authorised hereditary cancer products.

## Fields

- Kind: Test
- Status: established
- Last checked: 2026-11-04
- Also known as: BRCAPlus; Ambry BRCAplus
- Tags: test; hereditary
- Brand: BRCAplus
- Modality: Germline breast cancer gene panel (laboratory-developed test)
- Mechanism: Next-generation sequencing of 13 breast cancer susceptibility genes in germline DNA.

## Sources

- NIH Genetic Testing Registry GTR000560503.11: https://www.ncbi.nlm.nih.gov/gtr/tests/560503/
- NIH Genetic Testing Registry data file (test_version.gz): https://ftp.ncbi.nlm.nih.gov/pub/GTR/data/test_version.gz

## Connected records

- technologies: [Germline (hereditary) testing](https://onco.cc/technologies/germline-testing/)
- targets: [ATM](https://onco.cc/targets/atm/), [BRCA1 / BRCA2 (HRD)](https://onco.cc/targets/brca/), [CDH1](https://onco.cc/targets/cdh1/), [CHEK2](https://onco.cc/targets/chek2/), [NF1 (neurofibromin)](https://onco.cc/targets/nf1/), [PALB2](https://onco.cc/targets/palb2/), [PTEN](https://onco.cc/targets/pten/), [RAD51C](https://onco.cc/targets/rad51c/), [RAD51D](https://onco.cc/targets/rad51d/), [STK11](https://onco.cc/targets/stk11/), [TP53](https://onco.cc/targets/tp53/)
- companies: [Ambry Genetics](https://onco.cc/companies/ambry-genetics/)
- terms: [Germline BRCA mutation (gBRCA)](https://onco.cc/terms/gbrca-mutation/), [Hereditary cancer syndromes](https://onco.cc/terms/hereditary-cancer-syndromes/), [Hereditary diffuse gastric cancer](https://onco.cc/terms/hereditary-diffuse-gastric-cancer/)

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