# ANO7

Source: https://onco.cc/targets/ano7/  
OnCo record `ano7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.73).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: anoctamin 7; Anoctamin-7; PCANAP5L; IPCA-5; PCANAP5; TMEM16G
- Tags: cancer-genes-wave
- Symbol: ANO7
- Class: other
- Biology: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. Location: Cell membrane; Cell junction; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 2q37.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.57 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:31677: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31677
- UniProt Q6IWH7: https://www.uniprot.org/uniprotkb/Q6IWH7/entry
- NCBI Gene 50636: https://www.ncbi.nlm.nih.gov/gene/50636
- Ensembl ENSG00000146205: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146205

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/ano7.json