# AP3B1

Source: https://onco.cc/targets/ap3b1/  
OnCo record `ap3b1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.19, genetic association 0.00, somatic mutation 0.23, animal model 0.48).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: adaptor related protein complex 3 subunit beta 1; AP-3 complex subunit beta-1; ADTB3A; HPS2
- Tags: cancer-genes-wave
- Symbol: AP3B1
- Class: other
- Biology: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Golgi apparatus (UniProt). Locus 5q14.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:566: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:566
- UniProt O00203: https://www.uniprot.org/uniprotkb/O00203/entry
- NCBI Gene 8546: https://www.ncbi.nlm.nih.gov/gene/8546
- Ensembl ENSG00000132842: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132842

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ap3b1.json