# APBB1IP

Source: https://onco.cc/targets/apbb1ip/  
OnCo record `apbb1ip` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.97, animal model 0.50, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: amyloid beta precursor protein binding family B member 1 interacting protein; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; RARP1; PREL1; INAG1
- Tags: cancer-genes-wave
- Symbol: APBB1IP
- Class: other
- Biology: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Location: Cell membrane; Cell projection, lamellipodium; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10p12.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17379: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17379
- UniProt Q7Z5R6: https://www.uniprot.org/uniprotkb/Q7Z5R6/entry
- NCBI Gene 54518: https://www.ncbi.nlm.nih.gov/gene/54518
- Ensembl ENSG00000077420: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000077420

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/apbb1ip.json