# APH1A

Source: https://onco.cc/targets/aph1a/  
OnCo record `aph1a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

APH1A (Gamma-secretase subunit APH-1A) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.

## Summary

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: aph-1A gamma-secretase subunit; Gamma-secretase subunit APH-1A; APH-1A; CGI-78
- Tags: cancer-genes-wave
- Symbol: APH1A
- Class: other
- Biology: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Location: Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane (UniProt). Locus 1q21.2 (HGNC).
- Where found: Desmoid tumour: Open Targets association 0.50 with desmoid tumour (MONDO_0007608)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29509: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29509
- UniProt Q96BI3: https://www.uniprot.org/uniprotkb/Q96BI3/entry
- NCBI Gene 51107: https://www.ncbi.nlm.nih.gov/gene/51107
- Ensembl ENSG00000117362: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117362

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Desmoid tumour](https://onco.cc/cancers/desmoid-tumour/)

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JSON: https://onco.cc/api/v1/entities/aph1a.json