# APH1B

Source: https://onco.cc/targets/aph1b/  
OnCo record `aph1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

APH1B (Gamma-secretase subunit APH-1B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.

## Summary

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilising cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: aph-1B gamma-secretase subunit; Gamma-secretase subunit APH-1B; APH-1B; DKFZp564D0372
- Tags: cancer-genes-wave
- Symbol: APH1B
- Class: other
- Biology: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilising cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Location: Membrane (UniProt). Locus 15q22.2 (HGNC).
- Where found: Desmoid tumour: Open Targets association 0.50 with desmoid tumour (MONDO_0007608)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24080: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24080
- UniProt Q8WW43: https://www.uniprot.org/uniprotkb/Q8WW43/entry
- NCBI Gene 83464: https://www.ncbi.nlm.nih.gov/gene/83464
- Ensembl ENSG00000138613: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138613

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Desmoid tumour](https://onco.cc/cancers/desmoid-tumour/)

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JSON: https://onco.cc/api/v1/entities/aph1b.json