# AREG

Source: https://onco.cc/targets/areg/  
OnCo record `areg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AREG (Amphiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Head and neck squamous cell carcinoma and Non-small-cell lung cancer.

## Summary

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

CIViC holds 5 clinical evidence items and 0 assertions across 2 variants, naming Crizotinib, Cetuximab, Panitumumab and Docetaxel. Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.73, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: amphiregulin; Amphiregulin; CRDGF; AREGB
- Tags: cancer-genes-wave
- Symbol: AREG
- Class: other
- Biology: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Location: Membrane (UniProt). Locus 4q13.3 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease; Head and neck squamous cell carcinoma: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:651: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:651
- UniProt P15514: https://www.uniprot.org/uniprotkb/P15514/entry
- NCBI Gene 374: https://www.ncbi.nlm.nih.gov/gene/374
- Ensembl ENSG00000109321: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109321

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/areg.json