# ARHGAP26

Source: https://onco.cc/targets/arhgap26/  
OnCo record `arhgap26` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.

## Summary

GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.

Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.92, genetic association 0.51, somatic mutation 0.90, animal model 0.32).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho GTPase activating protein 26; Rho GTPase-activating protein 26; KIAA0621; OPHN1L; OPHN1L1
- Tags: cancer-genes-wave
- Symbol: ARHGAP26
- Class: other
- Biology: GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17073: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17073
- UniProt Q9UNA1: https://www.uniprot.org/uniprotkb/Q9UNA1/entry
- NCBI Gene 23092: https://www.ncbi.nlm.nih.gov/gene/23092
- Ensembl ENSG00000145819: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145819

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/arhgap26.json