# ARHGAP5

Source: https://onco.cc/targets/arhgap5/  
OnCo record `arhgap5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.

## Summary

GTPase-activating protein for Rho family members.

IntOGen calls it a driver in 7 cohorts (3 activating, 4 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma, Pleural Mesothelioma, Well-Differentiated Thyroid Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho GTPase activating protein 5; Rho GTPase-activating protein 5; RhoGAP5; p190-B; p190BRhoGAP; GFI2
- Tags: cancer-genes-wave
- Symbol: ARHGAP5
- Class: tumor-suppressor
- Biology: GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt). Locus 14q12 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 2 cohorts (BLCA); Multiple myeloma: IntOGen driver in 2 cohorts (PCM); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Thyroid cancer: IntOGen driver in 1 cohort (WDTC); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:675: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:675
- UniProt Q13017: https://www.uniprot.org/uniprotkb/Q13017/entry
- NCBI Gene 394: https://www.ncbi.nlm.nih.gov/gene/394
- Ensembl ENSG00000100852: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100852

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Papillary thyroid cancer](https://onco.cc/cancers/papillary-thyroid-cancer/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/arhgap5.json