# ARHGEF10

Source: https://onco.cc/targets/arhgef10/  
OnCo record `arhgef10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Cutaneous squamous cell carcinoma, Non-small-cell lung cancer and 1 more.

## Summary

May play a role in developmental myelination of peripheral nerves.

IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Bladder Urothelial Carcinoma, Cutaneous Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho guanine nucleotide exchange factor 10; KIAA0294; Gef10
- Tags: cancer-genes-wave
- Symbol: ARHGEF10
- Class: tumor-suppressor
- Biology: May play a role in developmental myelination of peripheral nerves. Locus 8p23.3 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Cutaneous squamous cell carcinoma: IntOGen driver in 1 cohort (CSCC); Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC); Small-cell lung cancer: IntOGen driver in 1 cohort (SCLC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14103: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14103
- UniProt O15013: https://www.uniprot.org/uniprotkb/O15013/entry
- NCBI Gene 9639: https://www.ncbi.nlm.nih.gov/gene/9639
- Ensembl ENSG00000104728: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104728

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Cutaneous squamous cell carcinoma](https://onco.cc/cancers/cutaneous-scc/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)

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JSON: https://onco.cc/api/v1/entities/arhgef10.json