# ARHGEF10L

Source: https://onco.cc/targets/arhgef10l/  
OnCo record `arhgef10l` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.

## Summary

Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Renal Clear Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho guanine nucleotide exchange factor 10 like; Rho guanine nucleotide exchange factor 10-like protein; FLJ10521; KIAA1626
- Tags: cancer-genes-wave
- Symbol: ARHGEF10L
- Class: tumor-suppressor
- Biology: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Location: Cytoplasm (UniProt). Locus 1p36.13 (HGNC).
- Where found: Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Basal cell carcinoma: IntOGen driver in 1 cohort (BCC); Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25540: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25540
- UniProt Q9HCE6: https://www.uniprot.org/uniprotkb/Q9HCE6/entry
- NCBI Gene 55160: https://www.ncbi.nlm.nih.gov/gene/55160
- Ensembl ENSG00000074964: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000074964

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/arhgef10l.json