# ARHGEF5

Source: https://onco.cc/targets/arhgef5/  
OnCo record `arhgef5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.82, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho guanine nucleotide exchange factor 5; TIM1; GEF5; P60
- Tags: cancer-genes-wave
- Symbol: ARHGEF5
- Class: other
- Biology: Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organisation. Plays a role in actin organisation by generating a loss of actin stress fibres and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Location: Cytoplasm; Nucleus; Cell projection, podosome (UniProt). Locus 7q35 (HGNC).
- Where found: Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13209: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13209
- UniProt Q12774: https://www.uniprot.org/uniprotkb/Q12774/entry
- NCBI Gene 7984: https://www.ncbi.nlm.nih.gov/gene/7984
- Ensembl ENSG00000050327: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000050327

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/arhgef5.json