# ARID2

Source: https://onco.cc/targets/arid2/  
OnCo record `arid2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARID2 (AT-rich interactive domain-containing protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Hepatocellular carcinoma, Oesophageal cancer and 5 more.

## Summary

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes.

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.98). IntOGen calls it a driver in 36 cohorts (3 activating, 33 loss-of-function), covering Cholangiocarcinoma, Cutaneous Squamous Cell Carcinoma, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Glioblastoma, Gallbladder Cancer and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: AT-rich interaction domain 2; AT-rich interactive domain-containing protein 2; KIAA1557; DKFZp686G052; FLJ30619; BAF200; SMARCF3; ZIPZAP; p200
- Tags: cancer-genes-wave
- Symbol: ARID2
- Class: transcription
- Biology: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Location: Nucleus (UniProt). Locus 12q12 (HGNC).
- Where found: Skin cancer: Open Targets association 0.67 with skin cancer (MONDO_0002898); Hepatocellular carcinoma: Open Targets association 0.63 with hepatocellular carcinoma (MONDO_0007256); CIViC evidence names this disease; Oesophageal cancer: Open Targets association 0.57 with oesophageal cancer (MONDO_0007576); IntOGen driver in 3 cohorts (ESCA, ESCC); Gastric & gastro-oesophageal junction cancer: IntOGen driver in 2 cohorts (STAD); Biliary tract cancer: Open Targets association 0.57 with biliary tract cancer (MONDO_0003060); Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 33 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:18037: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18037
- UniProt Q68CP9: https://www.uniprot.org/uniprotkb/Q68CP9/entry
- NCBI Gene 196528: https://www.ncbi.nlm.nih.gov/gene/196528
- Ensembl ENSG00000189079: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189079

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (all types)](https://onco.cc/cancers/biliary-tract-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Nasopharyngeal carcinoma](https://onco.cc/cancers/nasopharyngeal/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/arid2.json