# ARID5B

Source: https://onco.cc/targets/arid5b/  
OnCo record `arid5b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARID5B (AT-rich interactive domain-containing protein 5B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.

## Summary

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.

Open Targets scores its association with cancer at 0.43 (direct and indirect evidence; datatypes literature 0.26, animal model 0.53, genetic association 0.53).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: AT-rich interaction domain 5B; AT-rich interactive domain-containing protein 5B; FLJ21150; MRF2
- Tags: cancer-genes-wave
- Symbol: ARID5B
- Class: transcription
- Biology: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. Location: Nucleus (UniProt). Locus 10q21.2 (HGNC).
- Where found: Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.60 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17362: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17362
- UniProt Q14865: https://www.uniprot.org/uniprotkb/Q14865/entry
- NCBI Gene 84159: https://www.ncbi.nlm.nih.gov/gene/84159
- Ensembl ENSG00000150347: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150347

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/arid5b.json