# ARRB1

Source: https://onco.cc/targets/arrb1/  
OnCo record `arrb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ARRB1 (Beta-arrestin-1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signalling by mediating both receptor desensitisation and resensitisation processes. During homologous desensitisation, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalisation by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, animal model 0.48, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: arrestin beta 1; Beta-arrestin-1; ARR1
- Tags: cancer-genes-wave
- Symbol: ARRB1
- Class: transcription
- Biology: Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signalling by mediating both receptor desensitisation and resensitisation processes. During homologous desensitisation, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalisation by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalised arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalisation occur. Location: Cytoplasm; Nucleus; Cell membrane; Membrane, clathrin-coated pit (UniProt). Locus 11q13.4 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:711: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:711
- UniProt P49407: https://www.uniprot.org/uniprotkb/P49407/entry
- NCBI Gene 408: https://www.ncbi.nlm.nih.gov/gene/408
- Ensembl ENSG00000137486: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137486

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/arrb1.json