# ASNS

Source: https://onco.cc/targets/asns/  
OnCo record `asns` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ASNS (Asparagine synthetase [glutamine-hydrolysing]) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

Catalyses the ATP-dependent synthesis of L-asparagine from L-aspartate, using L-glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Asparaginase.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: asparagine synthetase (glutamine-hydrolyzing); Asparagine synthetase [glutamine-hydrolyzing]
- Tags: cancer-genes-wave
- Symbol: ASNS
- Class: enzyme
- Biology: Catalyses the ATP-dependent synthesis of L-asparagine from L-aspartate, using L-glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro. Locus 7q21.3 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:753: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:753
- UniProt P08243: https://www.uniprot.org/uniprotkb/P08243/entry
- NCBI Gene 440: https://www.ncbi.nlm.nih.gov/gene/440
- Ensembl ENSG00000070669: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070669

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/asns.json