# ASS1

Source: https://onco.cc/targets/ass1/  
OnCo record `ass1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.

## Summary

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Carboplatin, Cisplatin, Pegargiminase and Chloroquine and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: argininosuccinate synthase 1; Argininosuccinate synthase; CTLN1
- Tags: cancer-genes-wave
- Symbol: ASS1
- Class: enzyme
- Biology: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Location: Cytoplasm, cytosol (UniProt). Locus 9q34.11 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease; Sarcomas: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:758: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:758
- UniProt P00966: https://www.uniprot.org/uniprotkb/P00966/entry
- NCBI Gene 445: https://www.ncbi.nlm.nih.gov/gene/445
- Ensembl ENSG00000130707: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130707

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/ass1.json