# ATF7IP

Source: https://onco.cc/targets/atf7ip/  
OnCo record `atf7ip` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATF7IP (Activating transcription factor 7-interacting protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer and Non-small-cell lung cancer.

## Summary

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.61, somatic mutation 0.54). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: activating transcription factor 7 interacting protein; Activating transcription factor 7-interacting protein 1; FLJ10688; p621; ATF7IP1; MCAF1
- Tags: cancer-genes-wave
- Symbol: ATF7IP
- Class: tumor-suppressor
- Biology: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilises SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Location: Nucleus (UniProt). Locus 12p13.1 (HGNC).
- Where found: Endometrial cancer: IntOGen driver in 1 cohort (UCEC); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20092: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20092
- UniProt Q6VMQ6: https://www.uniprot.org/uniprotkb/Q6VMQ6/entry
- NCBI Gene 55729: https://www.ncbi.nlm.nih.gov/gene/55729
- Ensembl ENSG00000171681: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171681

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/atf7ip.json