# ATIC

Source: https://onco.cc/targets/atic/  
OnCo record `atic` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATIC (Bifunctional purine biosynthesis protein ATIC) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.

## Summary

Bifunctional enzyme that catalyses the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction.

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.93, genetic association 0.00, somatic mutation 0.90).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein ATIC; AICARFT; IMPCHASE
- Tags: cancer-genes-wave
- Symbol: ATIC
- Class: enzyme
- Biology: Bifunctional enzyme that catalyses the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyses the cyclisation of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukaemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalisation. Location: Cytoplasm, cytosol (UniProt). Locus 2q35 (HGNC).
- Where found: Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:794: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:794
- UniProt P31939: https://www.uniprot.org/uniprotkb/P31939/entry
- NCBI Gene 471: https://www.ncbi.nlm.nih.gov/gene/471
- Ensembl ENSG00000138363: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138363

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/atic.json