# ATP1A1

Source: https://onco.cc/targets/atp1a1/  
OnCo record `atp1a1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATP1A1 (Sodium/potassium-transporting ATPase subunit alpha-1) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Gastric & gastro-oesophageal junction cancer and Colorectal cancer.

## Summary

Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyses ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes clinical 0.18, affected pathway 0.32, literature 0.95, genetic association 0.00, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ATPase Na+/K+ transporting subunit alpha 1; Sodium/potassium-transporting ATPase subunit alpha-1
- Tags: cancer-genes-wave
- Symbol: ATP1A1
- Class: oncogene
- Biology: Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyses ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signalling pathway that senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake to regulate sodium homeostasis. Location: Cell membrane; Basolateral cell membrane; Cell membrane, sarcolemma; Cell projection, axon (UniProt). Locus 1p13.1 (HGNC).
- Where found: Breast cancer: IntOGen driver in 1 cohort (BRCA); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.18; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:799: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:799
- UniProt P05023: https://www.uniprot.org/uniprotkb/P05023/entry
- NCBI Gene 476: https://www.ncbi.nlm.nih.gov/gene/476
- Ensembl ENSG00000163399: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163399

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/atp1a1.json