# ATP2B3

Source: https://onco.cc/targets/atp2b3/  
OnCo record `atp2b3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.

## Summary

ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.51, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ATPase plasma membrane Ca2+ transporting 3; Plasma membrane calcium-transporting ATPase 3; PMCA3; CFAP39; SCAX1; CLA2
- Tags: cancer-genes-wave
- Symbol: ATP2B3
- Class: tumor-suppressor
- Biology: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established. Location: Cell membrane; Presynaptic cell membrane (UniProt). Locus Xq28 (HGNC).
- Where found: Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575); Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:816: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:816
- UniProt Q16720: https://www.uniprot.org/uniprotkb/Q16720/entry
- NCBI Gene 492: https://www.ncbi.nlm.nih.gov/gene/492
- Ensembl ENSG00000067842: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000067842

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

---
JSON: https://onco.cc/api/v1/entities/atp2b3.json