# ATXN1L

Source: https://onco.cc/targets/atxn1l/  
OnCo record `atxn1l` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATXN1L (Ataxin-1-like) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma and Melanoma.

## Summary

Chromatin-binding factor that repress Notch signalling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1).

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Vemurafenib, Trametinib and Dabrafenib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ataxin 1 like; Ataxin-1-like; BOAT1
- Tags: cancer-genes-wave
- Symbol: ATXN1L
- Class: transcription
- Biology: Chromatin-binding factor that repress Notch signalling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development. Location: Nucleus; Cell projection, dendrite (UniProt). Locus 16q22.2 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: CIViC evidence names this disease; Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:33279: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:33279
- UniProt P0C7T5: https://www.uniprot.org/uniprotkb/P0C7T5/entry
- NCBI Gene 342371: https://www.ncbi.nlm.nih.gov/gene/342371
- Ensembl ENSG00000224470: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000224470

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/atxn1l.json