# ATXN7

Source: https://onco.cc/targets/atxn7/  
OnCo record `atxn7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.

## Summary

Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex.

CIViC holds 4 clinical evidence items and 0 assertions across 5 variants.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ataxin 7; Ataxin-7; OPCA3; ADCAII; SGF73; SCA7
- Tags: cancer-genes-wave
- Symbol: ATXN7
- Class: transcription
- Biology: Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilisation. Involved in neurodegeneration. Location: Nucleus; Nucleus, nucleolus; Nucleus matrix; Cytoplasm, cytoskeleton (UniProt). Locus 3p14.1 (HGNC).
- Where found: Thyroid cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10560: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10560
- UniProt O15265: https://www.uniprot.org/uniprotkb/O15265/entry
- NCBI Gene 6314: https://www.ncbi.nlm.nih.gov/gene/6314
- Ensembl ENSG00000163635: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163635

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/atxn7.json