# AVL-101

Source: https://onco.cc/drugs/avl-101/  
OnCo record `avl-101` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AVL-101 is an experimental DNA-based therapeutic HPV vaccine from Beijing Xunsheng Biomedical Research, in phase 1 trials for cervical intraepithelial neoplasia grade 2/3 caused by HPV16/18.

## Summary

AVL-101 is a DNA-based therapeutic HPV vaccine from Beijing Xunsheng Biomedical Research, with Beijing Anweituo Biomedicine Co., Ltd., subsidiary and trial sponsor as partner. A therapeutic HPV vaccine, not a preventive one: the company says it works by activating cytotoxic T cells that recognise and clear cells carrying HPV16/18, aiming for regression of the lesion and clearance of the virus. Its furthest stage is phase 1, for cervical intraepithelial neoplasia grade 2/3 (CIN2/3) caused by HPV16/18 (a cervical precancer). No clinical trial naming it is registered on ClinicalTrials.gov. Phase 1 site initiation meetings held 9 July 2026 (Tianjin Medical University General Hospital) and 30 July 2026 (Cancer Hospital, Chinese Academy of Medical Sciences), per company news. It has not been shown to work in people.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline
- Code: AVL-101
- Modality: DNA-based therapeutic HPV vaccine
- Mechanism: A therapeutic HPV vaccine, not a preventive one: the company says it works by activating cytotoxic T cells that recognise and clear cells carrying HPV16/18, aiming for regression of the lesion and clearance of the virus.

## Sources

- Beijing Xunsheng Biomedical Research: aeonvital.com: http://www.aeonvital.com/wzxq?article_id=102
- Beijing Xunsheng Biomedical Research: aeonvital.com: http://www.aeonvital.com/wzxq?article_id=102
- Beijing Xunsheng Biomedical Research: aeonvital.com: http://www.aeonvital.com/page141

## Connected records

- companies: [Beijing Xunsheng Biomedical Research](https://onco.cc/companies/beijing-xunsheng-biomedical/)

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