# AXIN2

Source: https://onco.cc/targets/axin2/  
OnCo record `axin2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AXIN2 (Axin-2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer, Lung cancer and 2 more.

## Summary

Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Vemurafenib and Cobimetinib. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.96, genetic association 0.87, somatic mutation 0.92, animal model 0.38).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: axin 2; Axin-2; MGC126582; DKFZp781B0869
- Tags: cancer-genes-wave
- Symbol: AXIN2
- Class: other
- Biology: Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Location: Cytoplasm (UniProt). Locus 17q24.1 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.73 with colorectal cancer (MONDO_0005575); Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903); Neuroendocrine tumours: Open Targets association 0.51 with neuroendocrine neoplasm (MONDO_0019496); Chronic lymphocytic leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Ganglioglioma.

## Sources

- HGNC HGNC:904: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:904
- UniProt Q9Y2T1: https://www.uniprot.org/uniprotkb/Q9Y2T1/entry
- NCBI Gene 8313: https://www.ncbi.nlm.nih.gov/gene/8313
- Ensembl ENSG00000168646: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168646

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/axin2.json