# B4GALT1

Source: https://onco.cc/targets/b4galt1/  
OnCo record `b4galt1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

B4GALT1 (Beta-1,4-galactosyltransferase 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.

## Summary

Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: beta-1,4-galactosyltransferase 1; Beta-1,4-galactosyltransferase 1; beta4Gal-T1; GGTB2
- Tags: cancer-genes-wave
- Symbol: B4GALT1
- Class: enzyme
- Biology: Galactosyltransferase acting in the Golgi stacks. Catalyses the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms. Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions. Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine. With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Location: Golgi apparatus, Golgi stack membrane; Cell membrane; Cell surface; Cell projection, filopodium (UniProt). Locus 9p21.1 (HGNC).
- Where found: Renal cell carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:924: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:924
- UniProt P15291: https://www.uniprot.org/uniprotkb/P15291/entry
- NCBI Gene 2683: https://www.ncbi.nlm.nih.gov/gene/2683
- Ensembl ENSG00000086062: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086062

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/b4galt1.json