# BAG4

Source: https://onco.cc/targets/bag4/  
OnCo record `bag4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.95, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: BAG cochaperone 4; BAG family molecular chaperone regulator 4
- Tags: cancer-genes-wave
- Symbol: BAG4
- Class: other
- Biology: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria. Location: Cytoplasm (UniProt). Locus 8p11.23 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:940: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:940
- UniProt O95429: https://www.uniprot.org/uniprotkb/O95429/entry
- NCBI Gene 9530: https://www.ncbi.nlm.nih.gov/gene/9530
- Ensembl ENSG00000156735: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156735

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/bag4.json